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  Epub 2016 Apr 29  

Diagnosis of cardiac involvement in systemic amyloidosis by state-of-the-art echocardiography: where are we now?

Derliz Mereles, Matthias Aurich, Sebastian Greiner, Johannes Riffel, Sebastian J. Buss, Arnt V. Kristen, Hugo A. Katus

Echocardiography is the first-line imaging modality used to characterize heart compromise in systemic infiltrative diseases and to evaluate response to therapy. Cardiac amyloidosis results in progressive heart failure due to restriction of ventricular filling. However, in early stages, typical findings may not be evident, even when symptoms and signs of heart failure with preserved ejection fraction are already present. Identification of early compromise is now made possible with the advent of new echocardiography techniques as two-dimensional strain imaging ... Expert Opinion on Orphan Drugs 2016


  Epub 2016 Mar 24  

Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking

Matthias Aurich, Marius Keller, Sebastian Greiner, Henning Steen, Fabian aus dem Siepen F, Johannes Riffel, Hugo A. Katus, Sebastian J. Buss, Derliz Mereles

The assessment of left ventricular (LV) systolic function plays a central role in cardiac imaging. Calculation of ejection fraction (EF) is the current method of choice; however, its limited intermodal comparability represents a major drawback. The assessment of myocardial mechanics by strain imaging may better reflect the complex myocardial contractility. We aimed to evaluate different methods for quantification of LV strain on global and regional levels ... European Heart Journal - Cardiovascular Imaging 2016


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