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Publications

  Epub 2016 Apr 29  

Diagnosis of cardiac involvement in systemic amyloidosis by state-of-the-art echocardiography: where are we now?

Derliz Mereles, Matthias Aurich, Sebastian Greiner, Johannes Riffel, Sebastian J. Buss, Arnt V. Kristen, Hugo A. Katus

Echocardiography is the first-line imaging modality used to characterize heart compromise in systemic infiltrative diseases and to evaluate response to therapy. Cardiac amyloidosis results in progressive heart failure due to restriction of ventricular filling. However, in early stages, typical findings may not be evident, even when symptoms and signs of heart failure with preserved ejection fraction are already present. Identification of early compromise is now made possible with the advent of new echocardiography techniques as two-dimensional strain imaging ... Expert Opinion on Orphan Drugs 2016


  Epub 2016 Mar 24  

Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking

Matthias Aurich, Marius Keller, Sebastian Greiner, Henning Steen, Fabian aus dem Siepen F, Johannes Riffel, Hugo A. Katus, Sebastian J. Buss, Derliz Mereles

The assessment of left ventricular (LV) systolic function plays a central role in cardiac imaging. Calculation of ejection fraction (EF) is the current method of choice; however, its limited intermodal comparability represents a major drawback. The assessment of myocardial mechanics by strain imaging may better reflect the complex myocardial contractility. We aimed to evaluate different methods for quantification of LV strain on global and regional levels ... European Heart Journal - Cardiovascular Imaging 2016


  Epub 2015 Apr 21  

Diagnostic and prognostic value of a novel cardiac calcification score for coronary artery disease by transthoracic echocardiography

Kristóf Hirschberg, Manuel Reinhart, Mathias Konstandin, Lorenz Uhlmann, Hugo A. Katus, Derliz Mereles

Calcification of cardiac structures is associated with calcification of atherosclerotic lesions indicating a genetic predisposition for dystrophic calcifications. Furthermore, there are similar risk factors predisposing for coronary artery disease (CAD) and calcification of the mitral annulus and of other cardiac structures. The papillary muscle or ventricular septum was rarely evaluated in previous calcification scores. Thus, our study aimed to analyze the diagnostic and prognostic value of a new cardiac calcification score acquired by standard transthoracic echocardiography and to test its association with CAD phenotype ... International Journal of Cardiology 2015


  Epub 2014 Dec 18  

Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran and rivaroxaban), and bridging therapy in patients with atrial fibrillation and flutter

Maura M. Zylla, Mara Pohlmeier, Alexander Hess, Derliz Mereles, Meinhard Kieser, Thomas Bruckner, Eberhard Scholz, Edgar Zitron, Patrick A. Schweizer, Hugo A. Katus, Dierk Thomas

Direct oral anticoagulants (DOACs) are effective for stroke prevention in nonvalvular atrial fibrillation (AF). Cardioversion (CV) is frequently performed in patients with AF or flutter. To further explore the safety profile of DOACs in the context of CV, we sought to assess the prevalence of intracardiac thrombi under DOAC therapy in comparison with treatment with vitamin K antagonists. A total of 672 transesophageal echocardiograms performed in 643 patients ... The American Journal of Cardiology 2014


  Epub 2014 Oct 21  

Effects of ß-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction

Jin Li, Jennifer Franke, Regina Pribe-Wolferts, Benjamin Meder, Philipp Ehlermann, Derliz Mereles, Florian André, Mohamed Assem Abdelrazek, Constanze Merten, Patrick A. Schweizer, Rüdiger Becker, Hugo A. Katus, Dierk Thomas

Left ventricular noncompaction (LVNC) is a cardiomyopathy with hypertrabeculation of the LV, often complicated by heart failure, arrhythmia and thromboembolic events. The features of LVNC are still incompletely characterized due to its late recognition as clinically relevant condition. The aims of this study were to describe echocardiographic and electrophysiologic characteristics of LVNC patients and to assess the effects of chronic ß-blocker treatment. Study patients ... Clinical Research in Cardiology 2014


  Epub 2014 Aug 21  

Reliability of noninvasive assessment of systolic pulmonary artery pressure by Doppler echocardiography compared to right heart catheterization: analysis in a large patient population

Sebastian Greiner, Andreas Jud, Matthias Aurich, Alexander Hess, Thomas Hilbel, Stefan Hardt, Hugo A. Katus, Derliz Mereles

Pulmonary artery pressure (PAP) is an important marker in cardiovascular disorders, being closely associated with morbidity and mortality. Noninvasive assessment by Doppler echocardiography is recommended by current guidelines. So far, the reliability of this method has been assessed only in small studies with contradictory results. Therefore, the aim of this study was to analyze the reliability of noninvasive PAP assessment by Doppler echocardiography compared to invasive measurements in a large patient population ... Journal of the American Heart Association 2014


  Epub 2014 Aug 14  

Assessment of left ventricular volumes with echocardiography and cardiac magnetic resonance imaging: real-life evaluation of standard versus new semiautomatic methods

Matthias Aurich, Florian André, Marius Keller, Sebastian Greiner, Alexander Hess, Sebastian J. Buss, Hugo A. Katus, Derliz Mereles

Routine quantitative assessment of left ventricular (LV) volumes with echocardiography is hindered by time-consuming methods requiring a manual trace of the LV cavity from two apical two-dimensional planes. Thus, the aim of this study was to evaluate faster new semiautomatic echocardiographic methods that could represent ... Journal of the American Society of Echocardiography 2014 | Editorial


  Epub 2014 May 16  

Multiplane two-dimensional strain echocardiography for segmental analysis of right ventricular mechanics: NEW-RV study

Sebastian Greiner, Melissa Heimisch, Matthias Aurich, Alexander Hess, Hugo A. Katus, Derliz Mereles

Recent studies showed the prognostic value of strain measurements of the free right ventricular (RV) wall. The aim of this study was to evaluate the feasibility and the diagnostic value of the assessment of longitudinal mechanics of all segments of the RV by multiplane, two-dimensional transthoracic (2D) strain echocardiography ... Clinical Research in Cardiology 2014


  Epub 2014 Jan 23  

Classification of diastolic function with phase-contrast cardiac magnetic resonance imaging: validation with echocardiography and age-related reference values

Sebastian J. Buss, Birgit Krautz, Bernhardt Schnackenburg, Hassan Abdel-Aty, Maria Fernanda Braggion Santos, Florian André, Malte J. Maertens, Derliz Mereles, Grigorios Korosoglou, Evangelos Giannitsis, Hugo A. Katus, Henning Steen

Ojectives: To investigate whether cardiac magnetic resonance phase-contrast imaging (PC-CMR) can determine left ventricular (LV) diastolic function in comparison to echocardiography (EC). Background: Non-invasive evaluation of diastolic function is important for the diagnostic classification and risk stratification of patients with cardiomyopathies. With EC, diastolic function is classified based on the mitral blood flow, LV myocardial tissue Doppler velocities and pulmonary venous flow. PC-CMR has the potential to measure these parameters and may be an important tool to assess diastolic function in clinical routine ... Clinical Research in Cardiology 2014


  Epub 2013 Dec 7  

Quantitative analysis of left ventricular strain using cardiac computed tomography

Sebastian J. Buss, Felix Schulz, Derliz Mereles, Waldemar Hosch, Christian Galuschky, Georg Schummers, Daniel Stapf, Nina Hofmann, Evangelos Giannitsis, Stefan E. Hardt, Hans-Ulrich Kauczor, Hugo A. Katus, Grigorios Korosoglou

Objectives: To investigate whether cardiac computed tomography (CCT) can determine left ventricular (LV) radial, circumferential and longitudinal myocardial deformation in comparison to two-dimensional echocardiography in patients with congestive heart failure. Background: Echocardiography allows for accurate assessment of strain with high temporal resolution. A reduced strain is associated with a poor prognosis in cardiomyopathies. However, strain imaging is limited in patients with poor echogenic windows, so that, in selected cases, tomographic imaging techniques may be preferable for the evaluation of myocardial deformation ... European Journal of Radiology 2013


  Epub 2013 Nov 23  

Dobutamine stress cardiac magnetic resonance versus echocardiography for the assessment of outcome in patients with suspected or known coronary artery disease. Are the two imaging modalities comparable?

Eleni Bikiri, Derliz Mereles, A Voss, Sebastian Greiner, Alexander Hess, Sebastian J. Buss, Nina P. Hofmann, Evangelos Giannitsis, Hugo A. Katus, Grigorios Korosoglou

Purpose: To compare the value of Dobutamine stress echocardiography (DSE) with that provided by Dobutamine Cardiac Magnetic Resonance (DCMR) for the non-invasive risk stratification of patients with suspected or known coronary artery disease (CAD) ... International Journal of Cardiology 2013


  Epub 2012 Dez 4  

Non-invasive quantification of right ventricular systolic function by echocardiography: a new semi-automated approach

Sebastian Greiner, Florian André, Melissa Heimisch, Alexander Hess, Henning Steen, Hugo A. Katus, Derliz Mereles

Right ventricular (RV) function determines long-term outcome in many cardiopulmonary diseases. However, the assessment of RV function is time-consuming and surrogate parameters derived from two-dimensional (2D) or Doppler echocardiography show poor consistency ... Clinical Research in Cardiology 2012


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