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PublicationsEpub 2019 Mar 7
Pathophysiological background and prognostic implication of systolic aortic root motion in non-ischemic dilated cardiomyopathy
Matthias Aurich, Matthias Niemers, Patrick Fuchs, Sebastian Greiner, Matthias Müller-Hennessen, Lorenz Uhlmann, Evangelos Giannitsis, Philipp Ehlermann, Benjamin Meder, Hugo A. Katus, Derliz MerelesRecordings of aortic root movement represent one of the first accomplishments of ultrasound in medicine and mark the beginning of functional cardiac imaging. However, the underlying mechanism is not completely understood. Since the aortic root is directly connected to the cardiac skeleton we hypothesize, that the amplitude of systolic aortic root motion (SARM) may be mainly caused by displacement of the cardiac base towards the apex . . .
Scientific Reports 2019
Epub 2018 Sep 12
Prognostic relevance of the right ventricular myo-mechanical index (RV-MMI) in patients with precapillary pulmonary hypertension
Sebastian Greiner, Ferdinand Goppelt, Matthias Aurich, Hugo A. Katus, Derliz MerelesThe aim of the prospective New-RV study was to evaluate a parameter for non-invasive quantification of right ventricular (RV) dysfunction in patients with precapillary pulmonary hypertension (PH) that yields prognostic information and is applicable in daily clinical routine. Sixty-five consecutive patients with precapillary PH under guideline conform therapy (43 women, 22 men) underwent clinical assessment, serological testing, as well as a comprehensive transthoracic echocardiography . . .
Open Heart 2018
Epub 2018 Aug 6
Echocardiographic calcification score in patients with low/intermediate cardiovascular risk
Kristóf Hirschberg, Manuel Reinhart, Derliz Mereles, Lorenz Uhlmann, Florian André, Johannes Riffel, Marco Ochs, Hugo A. KatusCalcification of aortic valve and mitral annulus is associated with cardiovascular risk factors, morbidity and mortality. Assessment of cardiac calcification with echocardiography is feasible, however, only few structured scoring systems have been established so far with limited prognostic data. This study aimed to evaluate an echocardiographic calcification score (echo-CCS) in patients with low/intermediate cardiovascular risk . . .
Clinical Research in Cardiology 2018
Epub 2018 Mar 19
Systolic pulmonary artery pressure assessed during routine exercise Doppler echocardiography: insights of a real-world setting in patients with elevated pulmonary pressures
Susanne Korff, Patricia Enders-Gier, Lorenz Uhlmann, Matthias Aurich, Sebastian Greiner, Kristóf Hirschberg, Hugo A. Katus, Derliz MerelesPulmonary hypertension is a marker of disease severity. Exercise Doppler echocardiography (EDE) has proven to be feasible and reliable to assess pulmonary pressure. Increase in systolic pulmonary artery pressure (sPAP) has diagnostic and prognostic value in controlled studies. However, its value when assessed during routine examination in patients with cardiopulmonary diseases and resting sPAP?>?35 mmHg is not clearly defined. Clinical documentation and offline reevaluation of digitally stored EDE examinations of patients . . .
The International Journal of Cardiovascular Imaging 2018
Epub 2018 Feb 21
Unidimensional Longitudinal Strain: A Simple Approach for the Assessment of Longitudinal Myocardial Deformation by Echocardiography
Matthias Aurich, Patrick Fuchs, Matthias Müller-Hennessen, Lorenz Uhlmann, Matthias Niemers, Sebastian Greiner, Tobias Täger, Kristóf Hirschberg, Philipp Ehlermann, Benjamin Meder, Lutz Frankenstein, Evangelos Giannitsis, Hugo A. Katus, Derliz MerelesImpaired left ventricular (LV) longitudinal function (LF) is a known predictor of cardiac events in patients with heart failure, but two-dimensional strain imaging, the reference method to measure myocardial deformation, is not always feasible or available. Therefore, reliable and reproducible alternatives are needed. The aim of the present study was to evaluate unidimensional longitudinal strain (ULS) as a simple echocardiographic parameter for the assessment of LV LF. Two hundred two patients with dilated cardiomyopathy . . .
Journal of the American Society of Echocardiography 2018
Epub 2018 Jan 19
Prognostic relevance of elevated pulmonary arterial pressure assessed non-invasively: Analysis in a large patient cohort with invasive measurements in near temporal proximity
Sebastian Greiner, Andreas Jud, Matthias Aurich, Christoph Geisenberger, Lorenz Uhlmann, Thomas Hilbel, Meinhard Kieser, Hugo A. Katus, Derliz MerelesThe clinical relevance of non-invasively derived pulmonary arterial pressure (PAP) by Doppler echocardiography (DE) has been questioned in the past. However, transthoracic echocardiography is used as a cornerstone examination for patients with dyspnea and suspected pulmonary hypertension (PH). This study aimed to evaluate the prognostic value of non-invasive assessed PAP in a large population of patients with known or suspected cardiopulmonary disease. The analyses are based on data of patients of a tertiary cardiology center that received right heart catheterization (RHC) as well as non-invasively assessed PAP by DE within five days, and includes serological and clinical parameters in a retrospective follow-up for up to eight years . . .
PLoS One 2018
Epub 2017 Jan 30
Incremental value of cardiac magnetic resonance for the evaluation of cardiac tumors in adults: experience of a high volume tertiary cardiology centre
Sorin Giusca, Derliz Mereles, Andreas Ochs, Sebastian Buss, Florian André, Sebastian Seitz, Johannes Riffel, Philipp Fortner, Andrulis M, Sebastian Schönland, Hugo A. Katus, Grigorios KorosoglouTo assess the value of cardiac magnetic resonance imaging (CMR) in evaluating cardiac tumours in a tertiary cardiology centre. Between 2004 and 2014, 125 patients (pts.) from a total of 17000 who received a CMR examination in our institution were referred with the suspicion of cardiac tumours. A dedicated protocol was used that included standard cine SSFP acquisitions as well as tissue characterization using T1 and T2 . . .
The International Journal of Cardiovascular Imaging 2017
Epub 2017 Jan 30
A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation
Stefan M. Kallenberger, Christian Schmid, Felix Wiedmann, Derliz Mereles, Hugo A. Katus, Dierk Thomas, Constanze SchmidtParoxysmal atrial fibrillation (pAF) is a major risk factor for stroke but remains often unobserved. To predict the presence of pAF, we developed model scores based on echocardiographic and other clinical parameters from routine cardiac assessment. The scores can be easily implemented to clinical practice and might improve the early detection of pAF. In total, 47 echocardiographic and other clinical parameters were collected from 1000 patients with sinus rhythm (SR; n = 728), pAF (n = 161) and cAF (n = 111). We developed logistic models for classifying between pAF and SR that were reduced to the most predictive parameters. To facilitate clinical implementation, linear scores were derived. To study the pathophysiological progression to cAF, we analogously developed models for cAF prediction. For classification between . . .
PLoS One 2016
Epub 2016 Apr 29
Diagnosis of cardiac involvement in systemic amyloidosis by state-of-the-art echocardiography: where are we now?
Derliz Mereles, Matthias Aurich, Sebastian Greiner, Johannes Riffel, Sebastian J. Buss, Arnt V. Kristen, Hugo A. KatusEchocardiography is the first-line imaging modality used to characterize heart compromise in systemic infiltrative diseases and to evaluate response to therapy. Cardiac amyloidosis results in progressive heart failure due to restriction of ventricular filling. However, in early stages, typical findings may not be evident, even when symptoms and signs of heart failure with preserved ejection fraction are already present. Identification of early compromise is now made possible with the advent of new echocardiography techniques as two-dimensional strain imaging. Systemic amyloidosis is a rare disorder . . .
Expert Opinion on Orphan Drugs 2016
Epub 2016 Mar 24
Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking
Matthias Aurich, Marius Keller, Sebastian Greiner, Henning Steen, Fabian aus dem Siepen F, Johannes Riffel, Hugo A. Katus, Sebastian J. Buss, Derliz MerelesThe assessment of left ventricular (LV) systolic function plays a central role in cardiac imaging. Calculation of ejection fraction (EF) is the current method of choice; however, its limited intermodal comparability represents a major drawback. The assessment of myocardial mechanics by strain imaging may better reflect the complex myocardial contractility. We aimed to evaluate different methods for quantification of LV strain on global and regional levels . . .
European Heart Journal - Cardiovascular Imaging 2016
Epub 2015 Apr 21
Diagnostic and prognostic value of a novel cardiac calcification score for coronary artery disease by transthoracic echocardiography
Kristóf Hirschberg, Manuel Reinhart, Mathias Konstandin, Lorenz Uhlmann, Hugo A. Katus, Derliz MerelesCalcification of cardiac structures is associated with calcification of atherosclerotic lesions indicating a genetic predisposition for dystrophic calcifications. Furthermore, there are similar risk factors predisposing for coronary artery disease (CAD) and calcification of the mitral annulus and of other cardiac structures. The papillary muscle or ventricular septum was rarely evaluated in previous calcification scores. Thus, our study aimed to analyze the diagnostic and prognostic value of a new cardiac calcification score acquired by standard transthoracic echocardiography and to test its association with CAD phenotype . . .
International Journal of Cardiology 2015
Epub 2014 Dec 18
Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran and rivaroxaban), and bridging therapy in patients with atrial fibrillation and flutter
Maura M. Zylla, Mara Pohlmeier, Alexander Hess, Derliz Mereles, Meinhard Kieser, Thomas Bruckner, Eberhard Scholz, Edgar Zitron, Patrick A. Schweizer, Hugo A. Katus, Dierk ThomasDirect oral anticoagulants (DOACs) are effective for stroke prevention in nonvalvular atrial fibrillation (AF). Cardioversion (CV) is frequently performed in patients with AF or flutter. To further explore the safety profile of DOACs in the context of CV, we sought to assess the prevalence of intracardiac thrombi under DOAC therapy in comparison with treatment with vitamin K antagonists. A total of 672 transesophageal echocardiograms performed in 643 patients . . .
The American Journal of Cardiology 2014
Epub 2014 Oct 21
Effects of ß-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction
Jin Li, Jennifer Franke, Regina Pribe-Wolferts, Benjamin Meder, Philipp Ehlermann, Derliz Mereles, Florian André, Mohamed Assem Abdelrazek, Constanze Merten, Patrick A. Schweizer, Rüdiger Becker, Hugo A. Katus, Dierk ThomasLeft ventricular noncompaction (LVNC) is a cardiomyopathy with hypertrabeculation of the LV, often complicated by heart failure, arrhythmia and thromboembolic events. The features of LVNC are still incompletely characterized due to its late recognition as clinically relevant condition. The aims of this study were to describe echocardiographic and electrophysiologic characteristics of LVNC patients and to assess the effects of chronic ß-blocker treatment. Study patients . . .
Clinical Research in Cardiology 2014
Epub 2014 Aug 21
Reliability of noninvasive assessment of systolic pulmonary artery pressure by Doppler echocardiography compared to right heart catheterization: analysis in a large patient population
Sebastian Greiner, Andreas Jud, Matthias Aurich, Alexander Hess, Thomas Hilbel, Stefan Hardt, Hugo A. Katus, Derliz MerelesPulmonary artery pressure (PAP) is an important marker in cardiovascular disorders, being closely associated with morbidity and mortality. Noninvasive assessment by Doppler echocardiography is recommended by current guidelines. So far, the reliability of this method has been assessed only in small studies with contradictory results. Therefore, the aim of this study was to analyze the reliability of noninvasive PAP assessment by Doppler echocardiography compared to invasive measurements in a large patient population . . .
Journal of the American Heart Association 2014
Epub 2014 Aug 14
Assessment of left ventricular volumes with echocardiography and cardiac magnetic resonance imaging: real-life evaluation of standard versus new semiautomatic methods
Matthias Aurich, Florian André, Marius Keller, Sebastian Greiner, Alexander Hess, Sebastian J. Buss, Hugo A. Katus, Derliz MerelesRoutine quantitative assessment of left ventricular (LV) volumes with echocardiography is hindered by time-consuming methods requiring a manual trace of the LV cavity from two apical two-dimensional planes. Thus, the aim of this study was to evaluate faster new semiautomatic echocardiographic methods that could represent . . .
Journal of the American Society of Echocardiography 2014 + Editorial
Epub 2014 May 16
Multiplane two-dimensional strain echocardiography for segmental analysis of right ventricular mechanics: NEW-RV study
Sebastian Greiner, Melissa Heimisch, Matthias Aurich, Alexander Hess, Hugo A. Katus, Derliz MerelesRecent studies showed the prognostic value of strain measurements of the free right ventricular (RV) wall. The aim of this study was to evaluate the feasibility and the diagnostic value of the assessment of longitudinal mechanics of all segments of the RV by multiplane, two-dimensional transthoracic (2D) strain echocardiography . . .
Clinical Research in Cardiology 2014
Epub 2014 Jan 23
Classification of diastolic function with phase-contrast cardiac magnetic resonance imaging: validation with echocardiography and age-related reference values
Sebastian J. Buss, Birgit Krautz, Bernhardt Schnackenburg, Hassan Abdel-Aty, Maria Fernanda Braggion Santos, Florian André, Malte J. Maertens, Derliz Mereles, Grigorios Korosoglou, Evangelos Giannitsis, Hugo A. Katus, Henning SteenOjectives: To investigate whether cardiac magnetic resonance phase-contrast imaging (PC-CMR) can determine left ventricular (LV) diastolic function in comparison to echocardiography (EC). Background: Non-invasive evaluation of diastolic function is important for the diagnostic classification and risk stratification of patients with cardiomyopathies. With EC, diastolic function is classified based on the mitral blood flow, LV myocardial tissue Doppler velocities and pulmonary venous flow. PC-CMR has the potential to measure these parameters and may be an important tool to assess diastolic function in clinical routine . . .
Clinical Research in Cardiology 2014
Epub 2013 Dec 7
Quantitative analysis of left ventricular strain using cardiac computed tomography
Sebastian J. Buss, Felix Schulz, Derliz Mereles, Waldemar Hosch, Christian Galuschky, Georg Schummers, Daniel Stapf, Nina Hofmann, Evangelos Giannitsis, Stefan E. Hardt, Hans-Ulrich Kauczor, Hugo A. Katus, Grigorios KorosoglouObjectives: To investigate whether cardiac computed tomography (CCT) can determine left ventricular (LV) radial, circumferential and longitudinal myocardial deformation in comparison to two-dimensional echocardiography in patients with congestive heart failure. Background: Echocardiography allows for accurate assessment of strain with high temporal resolution. A reduced strain is associated with a poor prognosis in cardiomyopathies. However, strain imaging is limited in patients with poor echogenic windows, so that, in selected cases, tomographic imaging techniques may be preferable for the evaluation of myocardial deformation . . .
European Journal of Radiology 2013
Epub 2013 Nov 23
Dobutamine stress cardiac magnetic resonance versus echocardiography for the assessment of outcome in patients with suspected or known coronary artery disease. Are the two imaging modalities comparable?
Eleni Bikiri, Derliz Mereles, A Voss, Sebastian Greiner, Alexander Hess, Sebastian J. Buss, Nina P. Hofmann, Evangelos Giannitsis, Hugo A. Katus, Grigorios KorosoglouPurpose: To compare the value of Dobutamine stress echocardiography (DSE) with that provided by Dobutamine Cardiac Magnetic Resonance (DCMR) for the non-invasive risk stratification of patients with suspected or known coronary artery disease (CAD) . . .
International Journal of Cardiology 2013
Epub 2012 Dez 4
Non-invasive quantification of right ventricular systolic function by echocardiography: a new semi-automated approach
Sebastian Greiner, Florian André, Melissa Heimisch, Alexander Hess, Henning Steen, Hugo A. Katus, Derliz MerelesRight ventricular (RV) function determines long-term outcome in many cardiopulmonary diseases. However, the assessment of RV function is time-consuming and surrogate parameters derived from two-dimensional (2D) or Doppler echocardiography show poor consistency . . .
Clinical Research in Cardiology 2012
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