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  Epub 2024 May 23  

Prognostic relevance of global work index and global constructive work in patients with non-ischemic dilated cardiomyopathy

Peng Chen, Matthias Aurich, Sebastian Greiner, Gabriele Maliandi, Matthias Müller-Hennessen, Evangelos Giannitsis, Benjamin Meder, Norbert Frey, Sven Pleger, Derliz Mereles

Myocardial work (MW) derived from pressure-strain loops is a novel non-invasive tool to assess left ventricular (LV) function, incorporating global longitudinal strain (GLS) by speckle tracking echocardiography and non-invasively assessed blood pressure. Studies on the role of MW in dilated cardiomyopathy (DCM) are still limited. Therefore, the aim of this study was to evaluate the potential value of MW for predicting adverse outcomes in patients with DCM. 116 consecutive patients with DCM who underwent heart catheterization were retrospectively recruited . . .
The International Journal of Cardiovascular Imaging 2024

  Epub 2024 Feb 23  

Acute changes in cardiac dimensions, function, and longitudinal mechanics in healthy individuals with and without high-altitude induced pulmonary hypertension at 4559 m

Derliz Mereles, Jens Rudolph, Sebastian Greiner, Matthias Aurich, Norbert Frey, Hugo A Katus, Peter Bärtsch, Christoph Dehnert

High-altitude pulmonary hypertension (HAPH) has a prevalence of approximately 10%. Changes in cardiac morphology and function at high altitude, compared to a population that does not develop HAPH are scarce. Four hundred twenty-one subjects were screened in a hypoxic chamber inspiring a FiO2 = 12% for 2 h. In 33 subjects an exaggerated increase in systolic pulmonary artery pressure (sPAP) could be confirmed in two independent measurements . . .
Echocardiography 2024

  Epub 2023 Jul  

Prognosis of light chain amyloidosis: a multivariable analysis for survival prediction in patients with cardiac involvement proven by endomyocardial biopsy

Matthias Aurich, Julian Bucur, Johannes A Vey, Sebastian Greiner, Fabian aus dem Siepen, Ute Hegenbart, Stefan Schönland, Hugo A Katus, Norbert Frey, Derliz Mereles

Cardiac involvement is a main determinant of mortality in light chain (AL) amyloidosis but data on survival of patients with cardiac AL amyloidosis proven by endomyocardial biopsy (EMB) are sparse. This study analysed clinical, laboratory, electrocardiography and echocardiographic parameters for their prognostic value in the assessment of patients with AL amyloidosis and cardiac involvement. Patients with AL amyloidosis who had their first visit to the amyloidosis . . .
openheart 2023

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